Attenuates Intimal Hyperplasia in a Balloon-Injured Rabbit Iliac Artery Model Single Low-Dose Administration of Human Recombinant Hepatocyte Growth Factor
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چکیده
Satoshi Yasuda, Teruo Noguchi, Masahiro Gohda, Takashi Arai, Nobumasa Tsutsui, Takehisa Attenuates Intimal Hyperplasia in a Balloon-Injured Rabbit Iliac Artery Model Single Low-Dose Administration of Human Recombinant Hepatocyte Growth Factor Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.101.21.2546 2000;101:2546-2549 Circulation. http://circ.ahajournals.org/content/101/21/2546 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Single low-dose administration of human recombinant hepatocyte growth factor attenuates intimal hyperplasia in a balloon-injured rabbit iliac artery model.
BACKGROUND Previous studies have shown that repeated systemic administration of human recombinant hepatocyte growth factor (hrHGF) in mg/kg levels modulates the wound-healing process in various diseases. Recently, HGF has been characterized as one of the most potent endothelial-cell-specific growth factors. We tested our hypothesis that local delivery of hrHGF, even at low microg/kg levels (> o...
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The vitronectin receptor (alphavbeta3) mediates several biological processes that are critical to the formation of a neointima after coronary interventions. Blockade of alphavbeta3 could reduce neointima formation by inhibiting smooth muscle cell migration, decreasing transforming growth factor-beta1 expression, enhancing apoptosis, or reducing neovasculature. The effects of short-term administ...
متن کاملVitaxin, a Humanized Monoclonal Antibody to the Vitronectin Receptor (avb3), Reduces Neointimal Hyperplasia and Total Vessel Area After Balloon Injury in Hypercholesterolemic Rabbits
The vitronectin receptor (avb3) mediates several biological processes that are critical to the formation of a neointima after coronary interventions. Blockade of avb3 could reduce neointima formation by inhibiting smooth muscle cell migration, decreasing transforming growth factor-b1 expression, enhancing apoptosis, or reducing neovasculature. The effects of short-term administration of Vitaxin...
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